Biography
Akanksha Sharma is a Research Scholar, doing PhD. from Central University of Karnataka. She has completed her M.Pharm, from Central University of Punjab.
Abstract
Chemical investigation on Orthosiphon diffusus resulted in the isolation of two new polychiral furanopyrans, orthodiffenes E-F (5-6) along with earlier reported polychiral furanopyrans, orthodiffenes A-D (1-4) (Holla et al., 2011). The new molecules were characterized from the detailed studies of their 1D, 2D NMR spectra and mass spectra. Orthodiffenes A-D (1-4) has been reported earlier to be significantly cytotoxic against cancer cell lines (Holla et al., 2011). The new molecules orthodiffenes E-F (5-6) are expected to be cytotoxic against cancer cell lines due to structural similarity to orthodiffenes A-D (1-4).
Biography
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Abstract
Tea (Camellia sinensis) is the most popular beverages in the world and is rank second after the pure water. Tea has been considered as a health promoting beverage since ancient times due to its immune modulatory, anti-arthritic, anti-oxidant, anti-cancer and cardioprotective activity. Beside the beneficial effect few studies on animal models suggests, that the maternal intake of black tea has an adverse effect during pregnancy. The aim of the present study is to evaluate the role of Black Tea Extract (BTE) in experimental pregnant albino rat and to study the different physiological parameters of mother and pups during prenatal and postnatal developmental period. BTE was orally administered in LD (50mg BTE/kg/day) and HD (100mg BTE/kg/day) except control group of rats (n=6/group) throughout the prenatal and postnatal periods. During prenatal period (0, 7th, 14 th, 20 th days) body weight, urinary calcium, magnesium, urea and creatinine was measured. In postnatal period (0, 7th, 14 th, 20 th days)physical parameters of pups like body weight, weight of liver, kidneys, heart and lungs, cranial length, cranial diameter, neck width, tail length, craniosacral length of pups were analyzed. There was a significant (P=0.05) change in the weight of kidney, liver, lungs, heart and physical parameters in pups of treated groups as compared to control. The body weight of LD and HD mothers were also significantly (P=0.05) less than control mothers at 20th day of pregnancy. This study clearly indicates that BTE has some effect on pregnant mother in experimental animal model.