3^rd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products October 26-28, 2015 Hyderabad, India

Moiseev Dmitry has completed his specialist from pharmaceutical faculty (2002) and specialist from faculty of pedagogy and psychology (2011) of Vitebsk State Medical University. He has a Ph.D. degree in Pharmaceutical Sciences (2007). Since 2011 Dmitry Moiseev head of Department Standardization of Medicinal products of Vitebsk State Medical University. He has published more than 30 papers in reputed journals

Stress testing is defined as the stability testing of drug substances and drug products under conditions exceeding those used for accelerated testing. Stress testing provides information about degradation mechanisms and potential degradation products. The purpose of this work is to study the stability of substances of herbal origin by stress-testing. Various substances present in herbals and herbal medical products indicated in pharmacopoeias were taken into research. Chlorogenic acid in qualitative analysis of Urticae folia; ellagic acid - Alni glutinosae folia, caffeic acid - Taraxaci officinalis radices and Phaseoli vulgaris valvae fructus; arbutin – Vaccinii vitis-idaeae folia and Uvae ursi foliа, 20-hydroxyecdisone - Rhapontici carthamoides rhizomata cum radicibus and folia, glaucine – the main alkaloids of Glaucium flavum herba were used. The next conditions of stress-testing were chosen: hydrolysis in neutral (purified water), acid (0.01 M HCl) and alkaline (0.01 M NaOH) hydrolysis, treatment with 0.05 M aqueous solutions of ions of Cu2+ and Fe2+ for 14 days, and 0.1 and 2 % hydrogen peroxide for 24 h. The destruction of substances less than 15% during the period of storage was regarded as satisfactory result. It has been established that all investigated substances were stable in solutions of hydrogen peroxide and in purified water. Ellagic, chlorogenic and caffeic acids are unstable in solutions of alkaline, acids and metal ions. 20-Hydroxyecdysone was destructed in alkaline solution. These data can be used further in manufacturing processes or for selection of packing methods of medicinal herbals.

Prashanth D has completed his MBBS from MS Ramaiah Medical College, Bangalore and is presently pursuing his PG in Pharmacology in JJM Medical College, Davangere. He has one publication in his name and is presently involved in 2 research papers.

The worldwide use of herbal medicines has been increased over a past few decades. One or the other form of herbal medicine are used by around 80% of population atleast once in their life time. Herbal medicines have promising potential with respect to their efficacy is concerned but the major problem is that, most of the herbal products of interest remain untested, its monitoring is way far behind, and the knowledge of their pharmacokinetics and pharmacodynamics are poorly understood. So safety regarding the usage of these products has become a fundamental principle. WHO guidelines specifies that ADRs reported with the use of herbal products are mainly because of lack in quality, adulteration, inappropriate usage or due to the presence of pathogenic microorganisms. Also poor regulatory policies, improper quality control measures and unrestrained distribution of these products were suggested by WHO as additional factors for increase in the incidence of ADRs. Presence of multiple ingredients in the herbal products and its combination with conventional medications makes it difficult to identify the exact agent causing the adverse reaction; added to that, most of these products enter into the market without undergoing any clinical trials. Because of uninterrupted increase in use of herbal product there is a need to strengthen the regulatory system for quality and control of herbal medicine. Even though monitoring of these products has been included in the national pharmacovigilance program, there is a need to raise the awareness among the doctors and para medical staffs regarding the ADR reporting of these products. Hence the post marketing Pharmacovigilance plays a crucial role in monitoring the safety and efficacy of these herbal products and its accomplishment depends on awareness of National Pharmacovigilance Program among health care professionals

Kore Sharayu is M. D. In Ayurveda and Professor and HOD at Sumatibhai Shah Ayurveda mahavidhyalaya in Dravyaguna Vignyan(Pharmacology and Materia Medica). Reviewer for Research Aticles in International Journals AYU and JAIM.research commitee member of College. Has been working in T.B O.P.D since 2007. Has published articles in reputed Ayurvedic Journal. Has been Invited speaker at Update Ayurvda and National conference on Rajyakhma and Kushtha(T.B and Leprosy). Recepient of Annasaheb Patwardhan Vaidhyakeeya Puraskaar(V.M.Gogate vanoushadhi Purskaar) by Hon.Vaidya Khadiwale Vaidyak samshodhan Samshta. Co Convever at medicinal plant exhibition at World Ayurveda conferences 3 times.

In the world of Herbal drugs, Ayurveda has achieved the highest position. Presently it is one of the most popular ancient science in complimentary therapy.The scenario of Ayurveda has changed from treating only very chronic diseases and some cosmetology related problems to global health challenges like HIV and Tuberculosis. The efficacy of modern medicines also has some grey areas such as side effects , untowards or adverse effect which compel the patient to discontinue the treatment. Thus inspite of availablity of effective treatment the prevelance of disease is rising. HIV along with tuberculois aggravates the problem has reccommonded to give supportive therapy which will be useful to reduce side effects like gastritis or severe muscular weakness felt on the day of taking DOT medicines.rnSane Guruji Arogya Kendra is an authorised DOT centre where average 25 to 30 newly diagnosed cases of tuberculosis come annually.With the objective of reducing the side effects of the DOT the patients have been given supplimentary Ayurvedic medicines as mentioned above along with DOT. In awide range of patients it was observed that side effects were very well controlled. The obsevations were encouraging and thought provoking.Both the drugs were very well tolarated. Patient showed tremendous improvement in apetite, gained weight, had better quality of life. rnrnThe detail analysis of data showed that the given supplimentary therapy proved to be beneficial. It isrecommonded to take up multicentric trial based on this work. This can be a step towards contribution of Ayurveda to National health programme.

Vasundhara Srivastava did her M. Sc. In Chemistry in 1998 from University of Allahabad. She obtained her D. Phil. Degree in the year 2003 also from the same University. She has more than 13 years of teaching experience at undergraduate and post graduate levels . She has published 07 research papers in international and national journals of repute. For the last 10 years she is teaching in Amity university,NOIDA, Uttar Pradesh.

Medicinal plants contain bioactive components which are useful in the treatment of various diseases in human beings as well as play important role in healing . Phytochemicals may be braodly categorised into two categories : (a) primary constituents and (b) secondary constituents.rnThe primary constituents include sugars, proteins, amino acids and chlorophyll. The secondary constituents are mainly terpenoids an d alkaloids. Plants of medicinal importance have antifungal,antibacterial and anti inflammatory properties. The objective of of the present research work was to ascertain the presenceor absence of the major phytochemical constituents in the selected plants ofLeguminoseae and Convolvulaceae families.The results of the phytochemical analysis of these plants showed the presence of important components which have different medicinaly effects .The phytochemical analysis of plants has lot of commercial importance also as these may be further exploited on large scale in manufacturing drugs for the cure of various diseases.

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The chemical composition of volatile aroma compounds was determined in four samples of mountain tea (Sideritis raeseri), collected from four different localities in National Park Galichica in R. Macedonia on 2012 and 2013. Two types of plant material of each sample were analyzed: fresh flowering stems (homogenized samples from flower, leaf and stem) (F-S) and the fresh rosette leaves (F-RL). The analyses were made by gas chromatography – mass spectrometry (GC/FID/MS) on HP5-ms column and equipped with automated headspace system with heated syringe (HS) sampler. 0.3 g of fresh plant material was put in sealed vials, heated (5 minutes, 80 oC) and the gas phase was investigated. Total of thirtytwo individual components (15 monoterpenes representing 78.66-93.65% and 17 sesquiterpenes representing 3.97-20.10% of the entire volatiles) were identified as aroma components in F-S samples. The predominant components in all samples were β-pinene, α–pinene, δ-3-carene, limonene, α-сopaene and trans-сaryophyllene. In the F-RL samples of S. raeseri, 27 individual components were identified, 12 monoterpenes (51.90-87.08%) and 15 sesquiterpenes (7.22-46.59%). Prevailing components in all tested F-RL samples were β-pinene, α-pinene, limonene, α-сopaene, trans-сaryophyllene, germacrene D and δ-cadinene. There was almost no difference in the chemical profiles of the aroma compounds between F-S and F-RL. Fresh rosette leaves exhibit very similar aroma compounds profile with the flowering stems of Sideritis raeseri.

Sneha Vinodkumar Rathi is a student and she is studying in final year of B. Pharmacy, at Hi-tech College of Pharmacy, Chandrapur from Gondwana University. She has participated in Avishkar 2013 and also 2014 and has presented poster in the 8th Maharashtra State Inter-University Research Convection which was organized in North Maharashtra University, Jalgaon (M.S.). She has also presented a poster in the National Conference on Developmental Challenges of Carbon Nanotubes as a Vaccine Delivery which was organized in Sagar (M.P.).\r\n

Cassia fistula Linn. commonly known as the Golden Shower belongs to the family Fabacae. It is a medium size tree which is native of tropical Asia. It is widely cultivated in South Africa, East Africa, Brazil, India, West Indies, China, Mexico, etc. All parts of the plant have medicinal properties so it is a very valuable medicinal plant which is utilized in the traditional system of medicine. Phytochemical analysis showed the presence of important classes of phytoconstituents like anthraquinone glycosides, cardiac glycosides, flavonoids, phenolic compounds, carbohydrate, protein, fats, alkaloids, tannins, saponins, steroids, terpenoids and phlobatannins, linoleic acid, oleic acid, stearic acid, volatile compounds, etc. Leaves contain free rhein, sennosides A and B. Fruit contains anthraquinones, flavonoid-ol-derivatives, rhein, sennosides A and B, fistulic acids, potassium, calcium, iron and manganese. Flower contains ceryl alcohol, rhein, bianthraquinone glycoside, fistulin and kaempferol. Root contains betulinic acid, 7-methylphyscion and ß-sitosterol. Stem bark contains lupeol, ß-sitosterol and hexacosanol. Seeds are rich in glycerides with linoleic, oleic, stearic and palmitic acids as major fatty acids together with traces of caprylic and myristic acids. The plant has been reported to possess anti-bacterial, anti-fungal, anti-ulcer, anti-tussive, anti-diabetic, anti-pyretic, anti-itching, anti-parasitic, anti-oxidant, wound healing, laxative, hypolipidemic, protease-inhibitory and hepatoprotective activities.

Syeda Maryam completing his PhD next year at age of 31 years from University of Sao Paulo, Brazil in Plants sciences. She is working as Research assistant in Institute of Soil Science and Plant Cultivation (Warsaw- Poland). She has published three articles and 4 resumes

Plants secondary metabolites (PSM) can act as a toxin or detoxifying agents. Tannin and saponin are found in Brachiaria sp. in negligible and higher quantities, respectively. The managerial effects of swards on PSM in Brachiaria decumbens cv. Basilisk (BD) and Brachiaria brizantha cv. Xaraés (BB) in all seasons were observed. Sward managements comprised four levels of nitrogen fertilization (0, 150, 300 and 450 kg N/ ha) with two cutting heights (10 and 20 cm (BD) and 15 and 30 (BB)) in a complete randomized design (2x4x4) and season as a repeated measure. Sampling was done after every 28 days for phytochemical tests (saponin (foaming) and phenols (ferric chloride)). Foaming index varied only with season (P= 0.001) in BB, and lowest values were reported in spring (58.9±2.06%). However, in BD there was a significant interaction between all factors (P=0.0006) on foam stability. All seasons showed same results in non-fertilized swards under 450 kg N/ha, while lowest values were reported on treatments 300/20, 300/10 and 150/20, respectively in autumn, winter and spring. A significant interaction was found for all factors for phenols in BD and BB (P<0.0001). In BD, regardless of cutting heights and nitrogen, highest values were observed during summer and spring. While, in BB the highest phenol concentration occurred in summer and autumn or during summer and spring for all nitrogen levels on plant cutting heights of 15 cm and 30 cm, respectively. Overall, for both species, increasing on nitrogen fertilization tends to decrease phenols concentration. However, saponin varied with season of the year.

\r\nSai Sailesh Kumar G has completed his M.sc in Medical Physiology in 2007 from Manipal University and pursuing PhD under guidance of Dr R Archana (Guide) and Dr J K Mukkadan (co-guide). He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals\r\n

Gastritis is inflammation of the lining of the stomach. It may be short episode or may be of a long duration. The most common symptom is upper abdominal pain. Other symptoms include nausea and vomiting, bloating, loss of appetite, and heart burn. Gastritis is believed to affect about half of people and as people becomes aged the prevalence increases. Chronic gastritis is associated with ulcers and may increase risk for stomach cancer. Vestibular apparatus is located in the inner ear and helps for maintenance of balance and equilibrium. However, stimulating vestibular system in a controlled manner was found very beneficial and could prevent endocrine disorders like diabetes, hypothyroidism and relieves stress and anxiety. Natural method of stimulating vestibular system is by swinging on a swing according to the comfort. Aparna Sarkar and Debjani Guha et al., testified that vestibular stimulation effectively reduced secretion of acid from the stomach in animals and recommended vestibular stimulation as a natural therapy for gastric disorders. Hence there is a need to identify the need of vestibular stimulation and to conduct similar studies in human beings to validate vestibular stimulation in the treatment of gastric disorders.