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Aya Abd Elsalam Abo Elola Shokry

Cairo University, Faculty of Veterinary Medicine, Department of Pharmacology

Title: Some phytochemical, toxicological and pharmacological studies on apricot seed (Armeniace Semen) extracts.

Biography

Biography: Aya Abd Elsalam Abo Elola Shokry

Abstract

The present study was to investigate phytochemical, toxicological and some pharmacological activities of 70 %, 99.9% ethanolic extract of apricot seeds. The phytochemical screening was done for determination of total phenolics by the Folin–Ciocalteu method, total flavonoids by the aluminum chloride colorimetric method, total carotenoids and amygdalin content using HPLC. The toxicological studies was done for determination of LD50 in mice by oral administration of different doses of the extracts. The anti-inflammatory activity was done in vitro by determination of IC50 values for inhibition of the enzymes cyclooxygenase 1, 2 (COX-1, COX-2) and in vivo by formalin induced paw edema on rats. The analgesic activity was carried out on mice by writhing test and hot plate method. Phytochemical screening revealed that the amount of total phenolics was 179.4 and 191.2 ug gallic acid equivalent / g extract and the amount of total flavonoids was 226.18 and 509.34 ug rutin equivalent / g extract and the amount of total carotenoids was 0.145 and 0.156 mg/g extract and the amount of amygdalin was 5.72 g and 10.22 g / 100 g extract for 70 %, 99.9% ethanolic extract respectively. The toxicological studies revealed that both extracts has no toxic symptoms on rats , no mortalities appear on rats in different level of doses from 1 g to 10 g / kg BW. IC50 was 10.4, 0.33 and 7.45, 0.074 and 15.1, 0.049 Um for COX-1 and COX-2 for 70 %, 99.9% ethanolic extract, Celecoxib respectively. 70%, 99.9% ethanolic extract and amygdalin exhibited significant analgesic and anti-inflammatory activity in dose of 200 mg/kg BW. of both extracts and 50 mg/kg BW. for amygdalin.

Recent publications

  1. Baba, S. A. and Malik, S. A. (2015). Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii Blume. Journal of Tilbian University for Science, 9(4), 449-454.

 

  1. Badr, J. and Tawfik, M. K. (2014). Analytical and Pharmacological Investigation of Amygdalin in Prunus armeniaca L. Seeds. Journal of Pharmacy Research, 3(9), 2134-2137.

 

  1. Bolarinwa, I.F., Orfila, C. and Morgan, M.R.A. (2014). Amygdalin content of seeds, seeds and food products commercially-available in the UK. Food Chemistry, 152, 133-139.
  2. Chang, H.K., Yang, H.Y., Lee, T.H., Shin, M.C., Lee, M.H., Shin, M.S., Kim, C.J., Kim, O.J., Hong, S.P. and Cho, S. (2005). Armeniacae semen extract suppresses lipopolysaccharide-induced expressions of cycloosygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Biological and Pharmaceutical Bulletin, 28(3), 449-454.

 

  1. Hwang, H.J., Kim, P., Kim, C.J., Lee, H.J., Shim, I., Yin, C.S. and Hahm, D.H. (2008). Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biological and Pharmaceutical Bulletin, 31(8), 1559-1564.

 

  1. Hwang, H.J., Lee, H., Kim, C., Shim, I. and Hahm, D. (2008). Inhibitory Effect of Amygdalin on Lipopolysaccharide-Inducible TNF- α and IL-1 β mRNA Expression and Carrageenan-Induced Rat Arthritis. Journal of Microbiology and Biotechnology, 18(10), 1641-1647.

 

  1. Koo, J., Hwang, E., Cho, S., Lee, J., Lee, Y. and Hong, S. (2005). Quantitative determination of amygdalin epimers from armeniacae semen by liquid chromatography. Journal of Chromatography B, 814, 69-73.

 

  1. Korekar, G., Stobdan, T., Arora, R., Yadav, A. and Singh, S.B. (2011). Antioxidant Capacity and Phenolics Content of Apricot (Prunus armeniaca L.) Seed as a Function of Genotype. Plant Foods for Human Nutrition, 66, 376-383.

 

  1. Minaiyan, M., Ghannadi, A., Asadi, M., Etemad, M. and Mahzouni, P. (2014). Anti-inflammatory effect of Prunus armeniaca L.(Apricot) extracts ameliorates TNBS-induced ulcerative colitis in rats. Research in Pharmaceutical Sciences, 9(4), 225-231.

 

 

  1. Pradelles, P., Grassi, J. and Maclouf, J. (1985). Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: An alternative to radioimmunoassay. Analytical Chemistry, 57(7), 1170-1173.