Pharmacognosy, Phytochemistry & Natural Products

Biography

Biography: Saba Maanvizhi

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various essential organs. Several essential metals are required for the proper functioning of many enzymes, transcriptional factors and proteins important in various biochemical pathways. Poor glycemic control and diabetes alters the levels of essential trace elements such as Zn, Mg, Mn, Cr, Fe etc. by increasing urinary excretion and their concomitant decrease in the blood. Conventional treatment strategies use of antidiabetic drugs, often fail due to their poor solubility, lower bioavailability and ineffectiveness to elicit therapeutic action. Nanotechnology is one approach to overcome challenges of conventional drug delivery systems based on the development and fabrication of nanoscale drug delivery systems, have been employed to optimize therapeutics.Hence, the main purpose of this study mainly focuses on the preparation and characterization of Embelin-Zinc nanoparticles by emulsification cross linking method using chitosan as a polymer for prolonged release. The objective of the study was to develop a nanoparticle for antidiabetic efficacy and also to maintain constant plasma drug concentrations over a prolonged period for effective control of blood sugar levels. The shape, surface morphology, drug – polymer interaction and thermal stability of embelin-zinc nanoparticles were confirmed by different characterization techniques. The prepared nanospheres exhibited prolonged drug release (more than 8 hrs) and all other data confirmed satisfactory results and the substitution of transition metals influences strongly the nanostructure of the prepared compound and moreover find use in the management and treatment of diabetes and diabetes-associated complications.