Azza ELMedany
Alexandria University, Egypt
Title: Chemotherapeutic Antitumor Activities of Curcumin on N-methyl-N- Nitrosourea Induced Mammary tumors in Female Rats
Biography
Biography: Azza ELMedany
Abstract
The limited ability of current treatments to control metastasis and the proposed antitumor pracurcumin , the active ingredient from the spice turmeric on the development of N-methyl-N-nitrosourea (MNU) –induced mammary tumors in female rats. A thirty female rats were divided into normal control (10rats ) . Carcinogenic rats ( 20 rats) in which a single I.P. dose of MNU 50mg/kg was injected. Two weeks after the rats divided into two groups each of 10 rats. Control carcinogenic rats & treated group with curcumin in a dose of 160mg/kg orally daily . After 24 weeks the rats were killed tumors excised & processed. Curcumin reduced the incidence of MNU- induced mammary tumors & tumor,s numbers by 58.2% & tumor burden by 50.5%. The tumor weights/rat was decreased by 35% .In addition 40% of carcinogenic rats developed ulcerated tumors, in contrast to 10% in treated rats. Curcumin significantly elevated GSH & reduced the elevations of MDA, TNF-α, TGF-β& COX2 in mammary carcinomatous tissues. In addition , curcumin tended to normalize back the histological changes retrieved in carcinomatous cells induced by MNU. These findings suggest that that curcumin significantly reduced the incidence & growth of MNU-induced mammary tumors & has strong potential therapeutic regimen for inhibiting & treating cancer breast.