Hesham R El-Seedi
Karolinska University Hospital, Sweden
Title: The traditional and prophetic medicines, role of secondary metabolism, and the un-expected results!
Biography
Biography: Hesham R El-Seedi
Abstract
Firstly, the talk will cover our characterization of un-expecting bioactive naturally occurring compounds from traditional medicinal plants. The first topic reflects our discovery of mescaline (1) from peyote. The compound displayed psychotropic properties and peyote samples appear to be the oldest plant drug ever to yield a major bioactive compound i.e. as long as 5700 years ago.1 Then the recent change of chemosystematic significance will be introduced demonstrating the isolation of new unusual cyclopeptide alkaloid (2) in addition to integer-rine (3) from Heisteria nitida.2 It was discovered in the family Olacaceae for first time.3 Beside discussion of the possible applications including anti-microbial, anti-schistosomiasis, anti-inflammatory antigenotoxic and antioxidant activities. For instance, unexpected new aryl coumarin glucoside (4) and its aglycon (5) from Asphodelus microcarpus, showed potent anti-microbial activity.4 In addition to luteolin-7-O-glucoside (6) from Mongolian medicinal plant Leptopyrum fumarioides L that was evaluated as antigenotoxic and antioxidant. In in vitro study, it was found to inhibit the DNA damage induced by catechol.5 As well as proscillaridin A (7) from Urginea maritima, one of the Sinai palnts show cytotoxic activity against human lymphoma U-937 GTB cell line. Finally the talk will be highlighting the action of isolated peptides from medicinal plants such as cystine knot peptide from Cactaceae family; Ep-AMP1 (8) from Echinopsis pachanoi L., sequencing, chemical synthesis, three-dimensional solution structure and bioactivity of this compound was determined as antimicrobial.6 Morever, Peptide RCB‑1 (9) from Ricinus communis L. RCB-1 compound was proved positive as antibacterial, antifungal, and cytotoxic compound, and was remarkably stable.7 On the other hand, the importance of Prophetic medicine as one of the oldest traditional plants prescriptions developed in the Golden Age of the Islamic civilization, which extended from Spain in the west to Central Asia and India in the east. Where the medicine was a central part and in temporal terms it covered a period of roughly nine centuries.8 There are many and various secondary metabolisms isolated from medicinal plants mentioned in Holy Qura`n and Ahadith such as (Allium cepa L; Basal, A. sativum L; Foom) and (Brassica spp.; Khardel). These secondary metabolisms include Hydrocinnamic acids (Feurlic (10) and sinapic acids (11)). According to its biological activity, feurlic and sinapic acids in clinical practices used as anti-oxidant, anti-microbial, neuroprotective, radioprotective, pulmonary protective, anti-atherogenic effect and to treat breast cancer.