Pharmacognosy, Phytochemistry & Natural Products

Biography

Biography: Akkal Salah

Abstract

The Apiaceae family is represented in Algeria by 28 genus and 146 species. Among this family, many plants of the genus are widely used in local herbal medicine, as they show a wide range of pharmacological activities. Many species of Apiaceae were used in folk medicine, as spices in cookery, but also as official medicinal drugs [1, 2].Thus, they account as a well-known source of essential oils and important herbal products. They are included in various pharmacopoeias as antiseptic, expectorant, diuretic, carminative, vasodilator, or spasmolytic agents [3]. The purpose of this research concerns the phytochemical and the biological study of of some genus of the Algerian flora’s medicinal plants known as Return, Formula, Bupleurum, Daucus. The diverse methods of separation and purification of the methanolic extract of these plants to obtain many constituents. Many compounds belonging to different classes of secondary metabolites were isolated for the first time from the aerial parts of some species. These include flavonoids, coumarines, terpenoides an epoxide and a sugar which contributed to the diversity of natural products in the species. The structure elucidation of the isolated compounds was based on analyses of their spectroscopic data (1D and 2D NMR, UV, MS). Structure elucidations of the phytoconstituents were achieved using various spectroscopic methods such as 1D (1H, 13C) and 2D (COSY, HMQC, HMBC, NOESY) NMR, MS, IR and UV-Vis and by comparison of their data with those of published compounds. Analyses of the extracts by gas chromatography and GC-mass spectrometry (GC-MS) tentatively identified many compounds, the various extracts and isolated compounds of this species were studied for their antioxidant and antimicrobial activities. The isolation of these biological active compounds showed the real importance to investigate plants that can be sources of new com- pounds with clinical activities