Farid A. Badria
Mansoura University, Egypt
Title: Natural products as human aldose reductase inhibitors
Biography
Biography: Farid A. Badria
Abstract
Aldose reductase (AR) has been a drug target because of its involvement in the development of secondary complications of diabetes including cataract. Although numerous synthetic AR inhibitors (ARI) have been tested and shown to inhibit the enzyme, clinically synthetic ARIs have not been very successful. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. In the present study we have assessed the inhibition of AR using natural products both in vitro and in lens organ. Bioguided fractionation assays were used for inhibition against both rat lens and purified recombinant human AR. Out of 68 tested plant extracts only 7 were able to inhibit rat lens and recombinant human AR. Quercetin, Kaempferol and Ellagic acid is promising naturally occurring are potent inhibitors of AR and suggest that exploring the therapeutic value of natural ingredients that people can incorporate into everyday life may be an effective approach in the management of diabetic complications.