Mansour S
University of Mostaganem, Algeria
Title: Anti-inflammatory activity of the aqueous extract of Artemisia absinthium in inflammatory paw edema model in mice
Biography
Biography: Mansour S
Abstract
Artemisia absinthium (Asteraceae) is a medicinal plant used in the treatment of many diseases including inflammatory diseases component. The purpose of this study was to evaluate the anti-inflammatory activity oral administration of aqueous extract of Artemisia absinthium leaves at doses of 150 and 300 mg / kg PC, by carrageenan induced paw edema in mouse model. At the end of the experiments, histological study is conducted. Our results show that the injection of the carrageenan causes a significant increase in paw volume of the mice. Oral administration of diclofinac (50 mg / Kg bw) causes a reduction in paw volume of the mice over the six hours of experimentation. Moreover, after one hour, the percentage inhibition of the aqueous extract of Artemisia absinthium at a dose of 150 mg / kg bw was 43%, the activity increases up to the sixth hour (90%). Similarly, at a dose of 300 mg / Kg bw the inhibitory effect of the extract of Artemisia absinthium starts and gradually increases during the experimentation (77% to 96% by H1 and H6). Histological examination of paw mice treated by diclofinac and by the aqueous extract of Artemisia absinthium (150 and 300 mg / kg bw) confirm that these treatments have anti-inflammatory activity. Furthermore, at a dose 300 mg / kg bw, the inflammatory infiltrate disappears almost completely. The results of this study showed that the aqueous extract of Artemesia absinthium has an efficacy in acute paw edema in mice induced by carrageenan, with greater efficiency at a dose of 300 mg/kg bw as compared to that of 150 mg/kg bw and that of the non-steroidal anti-inflammatory.