Chaitanya Sravanthi Kota
JNTU University, India
Title: Priliminary phytochemical investigation and pharmacological screening of caseariaellipticabark for antidiabetic activity
Biography
Biography: Chaitanya Sravanthi Kota
Abstract
The metabolic disorder which has become more common in world population is Diabetes mellitus. Ample number of formulations of medicines for Diabetes are available but still this disorder requires a search for a drug with no or considerablely less side effects. This thought gave scope for complementary therapies. A study on bark of Casearia elliptica was conducted for evaluation of antidiabetic activity in STZ induced diabetic rats. Rats of body weight 180-200gms were administered with STZ dose 60 mg/kg body weight to induce diabetes. Five rats were placed in each group . Rats were grouped into Normal group (Group I) ,Diabetic control treatedwith STZ (Group II), Diabetic rats treated with Glibenclamide (Group III), Diabetic rats treated with Casearia elliptica bark extract(Group IV). Group III is administered with 10mg/kg of standard drug Glibenclamide .The Caseariaelliptica extract were administered with doses of 200mg/kg & 400mg/kg using CMC solution (5%) as the vehicle. Blood glucose in Group IV,III,II, I, on 14th day were 164.4±1.29, 98.8 ±1.15, 291±0.71,107±1.14 respectively . Observation shows that standard is one and half times morepotent than Group IV in hypoglycemic effect at a dose of 200mg/kg.. Body weights of Group IV , III , II,I and on 14th day were198.22±1.23, 187.2±0.96, 165.8±1.2,193.5 ±1.5, and with no toxic effects were observed in the Test Group (Group IV). Body weights and blood glucose levels were compared with Group II. Proteins,Carbohydrates;secondary metabolites like Alkaloids, Steroids ,Saponins and Flavonoids were present in Casearia elliptica which were detected by preliminary chemical tests