Purbajit Chetia
Assam Down Town University, India
Title: Plant derived biomolecules significantly decrease oxidative stress in isolated inflammatory lymphocytes of patients with Rheumatoid Arthritis: An ex vivo study.
Biography
Biography: Purbajit Chetia
Abstract
Rheumatoid arthritis (RA) is a chronic, autoimmune and systemic inflammatory disorder that mainly attacks synovial joints resulting in an unchecked synovial inflammation that leads to increased oxidative stress in peripheral blood inflammatory cells. RA typically affects the joints of hands and feet, although any joint in the body may be affected such as wrists, knees, hips and shoulders resulting in permanent damage, bone destruction and deformity. The precise etiology of RA remains still unknown, but studies have implicated a role for oxidative stress and redox signaling in its pathogenesis. Lymphocytes are considered to play a key role in the pathogenesis of inflammatory diseases like RA. The disease is consistently associated with an increase in various pro-inflammatory factors that include cytokines (IL-1 β, IL-6, tumor necrosis factor alpha TNF- α), prostaglandins and also reactive oxygen and nitrogen species (ROS/RNS) at sites of inflammation that leads to damaging of cellular elements in cartilage and components of the extracellular matrix like protein and lipid. This present study was aimed to evaluate the ex vivo effect of plant derived biomolecules (β-carotene and Naringenin, which are already proved to have free radical scavenging property) on generation of free radicals in isolated blood lymphocytes of patients with RA. Interestingly it was found that these biomolecules significantly inhibited the superoxide, hydroxyl and NO radicals attenuating oxidative stress in the isolated peripheral blood mononuclear lymphocytes of patients with RA that admire further studies on other human inflammatory cells.