Juliao A Monjane
Eduardo Mondlane University, Mozambique
Title: Phytochemical investigation of Cadaba natalensis roots
Biography
Biography: Juliao A Monjane
Abstract
The roots of Cadaba natalensis (Capparaceae family), known as Tssatssassana or Ndoda Ya Munhama in Southern Mozambique have been used to treat tuberculosis. Several species of the genus Cadaba have been studied phytochemically, although no previous studies have been carried out on C. natalensis. The aim of this work was to isolate and characterize some phytochemical constituents present in the roots of this plant. The isolation of the compounds was done by chromatographic methods and two novel compounds together with five known compounds were isolated. The novel compounds were by spectroscopic techniques characterized as dimeric a tetrahydroisoquinoline similar to thalifoline and 4-oxazolidine derivatives, and a 2-oxazolidine derivative that for the first time was obtained from a natural source. This is the first study in which the rare five membered ring structures (2 and 4-oxazolidine derivatives) are isolated from a plant, although similar compounds have previously been isolated from marine sources. Beside these three compounds, also thalifoline, N-methylcorydaldine, β-sitosterol, and nepetin were obtained. The 2 and 4-oxazolidine derivatives have been reported to possess antimicrobial, antibacterial, and anticancer activities, while tetrahydroisoquinoline derivatives can have vasorelaxant activity. The structures of isolated compounds were characterized by 1D and 2D NMR spectroscopy, HRESI-MS, and by the comparison with the reported spectroscopic data for the known ones.
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