Behzad Mohaddesi
Saurashtra University, India
Title: Phytochemical evaluation and anti cancer screening of cardiospermum halicacabum Seeds extracts on different Human Cancer Cell Lines
Biography
Biography: Behzad Mohaddesi
Abstract
In modern life the growth of different acute and chronic disease increased and cancer is one of the disorders with significant prevalence rate among them. As knowledge has increased about the traditional medicine, the daily interest to use of natural products especially herbal drugs are becoming more from patients to physicians with aim to prevention of disease and safer way of treatment with lesser side effect for such conditions. Hence, this study undertaken to evaluate the effect of cardiospermum halicacabum a traditional medical plant. Cardiospermum halicacabum Linn. from Sapindaceae family, known as love in a puff in English and karṇasphoá¹a in Hindi. Different part of this plant such as leaves, fruits and seeds are traditionally used for treatment of various diseases in different system of medicine such as Ayurveda, Chinese, Homeopathy and Unani. The seeds of plant selected for this study and subjected to soxhlet extraction to obtain the various extracts, preliminary phytochemical studies performed for each extract and individually tested against four human cancer cell lines, HT-29, HCT-15, SK-MEL-2 and MCF7 with Sulforhodamine B colorimetric (SRB) cytotoxicity assay and compared with Doxorubicin a known anti cancer drug. The most active extract selected and subjected to phytochemical analysis by GC-MS to find out the probable active components. Result of this work indicated the potential medicinal value of cardiospermum halicacabum seeds as anti-neoplastic agents on human cancer cell and the GS-MS analysis showed the present of different fatty acids in the seed extract which can be responsible for the anti cancers activity.
