Muralidhar Rao Akkaladevi
Maheshwara Institute of Pharmacy, India
Title: Nano formulations of bioactive natural products for the treatment of cancer
Biography
Biography: Muralidhar Rao Akkaladevi
Abstract
According to the NNI, Nanotechnology is the understanding and control of matter at dimensions between approximately 1 and 100 nanometers (nm), where unique phenomena enable novel applications not feasible when working with bulk materials or even with single atoms or molecules. Nanotechnology is ideally suited for drugs with solubility problems .One of the key factors affecting bioavailability of drugs is solubility. Many bioactive natural products have poor water solubility .Nanotechnology has the potential to give new breath of life to those bioactive natural products which were rejected due to their poor solubility. Poorly soluble drugs can also be solubilized by other conventional methods. But those methods have various limitations. The nanocrystal technology enables formulations to be developed without the need of toxic surfactants (e.g. Cremophor EL) which may cause enhanced side effects or adverse reactions. Taxol formulation was very difficult because of hydrophobicity. It is made into liquid formula by dissolving it in a solvent called Cremophor. Many people react badly to this solvent and when administered intravenously experienced neurotoxicity. Abraxis, developed a form of Paclitaxel using nanoparticles of protein called Albumin. This protein can bind bind to receptors in blood vessels. Tumor response rate was twice as good for the nano formulated drug. Only 30 minutes are needed for a complete IV dose of the drug instead of three hours. Thus reduced side effects improved quality of life.
