shyamala chennaboina
Kakatiya university, India
Title: Hepatoprotective activity of Murraya koenigii leaf extract on paracetamol induced hepatic damaged rats.
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Biography: shyamala chennaboina
Abstract
In the present study protective effect of Murraya koenigii leaf extract was investigated against paracetamol induced hepatotoxicity and compared with silymarin a standard hepatoprotective reference drug. Methanolic extract was prepared by uing soxhlet method. Male Albino wistar rats were divided into 5 groups. Rats except of control group received a single dose of paracetamol (2gm/kg.b.wt) on 7th day,silymarin (100mg/kg.b.wt) and extract (200 and 400mg/kg.b.wt ) for 7 days. On the 7th day blood samples were collected by retro orbital puncture and liver marker enzymes (sgot,sgpt,alkaline phosphatase),total protein,total bilirubin levels were estimated in serum and histopathologicl observations were done for the isolated livers. In the toxic group paracetamol treatment lead to elevated level of liver marker enzymes and bilirubin and there was deterioration of total protein content. However treatment with Murraya koenigii shows a significant results (p<0.05) in comparision with standard drug. Thus the results clearly demonstrate that murraya koenigii possess promising hepatoprotective activity,hence suggests its use as potential therapeutic agentfor protection from paracetamol overdose.
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