Pharmacognosy, Phytochemistry & Natural Products

Biography

Biography: Shashikala G

Abstract

Learning is defined as the acquisition of information and skills, and subsequent retention of that information is called memory. Learning and memory can be a psychological process as well as a change in synaptic neural connectivity. Memory is the most common cognitive ability lost with dementia. The study was undertaken to evaluate the learning & memory effect of Alcoholic extract of Tinospora cardifolia in alprazolam induced amnesic mice.The study was carried out on albino mice, divided into 4 groups of 6 animals each (3-4months of age, weight 25-30g). Amnesia was induced by administering Alprazolam (2mg/kg body wt for 14 days) in all 4 groups for 14days from 1st to 14th day.Group 1 would be given memory impairing dose of Alprazolam (2mg/kg/p.o) alone for 14days. Group 2 would be given Piracetam (400mg/kg p.o) from 8th to 15th day. Group 3 would be given Alcoholic extract of Tinospora cordifolia 140 mg/kg, p.o. from 1st to 15th day. Group 4 would be given Alcoholic extract of Tinospora cordifolia 280 mg/kg, p.o. from 1st to 15th day.The learning and memory of the animals was assessed by employing Elevated plus maze [transfer latency (TL)] & Step-down type passive avoidance model[step down latency (SDL)]. The measured parameters TL & SDL were compared with standard drug Piracetam. In both EPM & SDA model results were comparable with the standard. Tinospora cardifolia, Indian medicinal plant useful for treatment of various ailments like Diabetes,Rheumatoid arthritis,Gout,Viral hepatitis,Gonorrhoea,Syphilis and Anemia can also be a useful alternative for treating Dementia and associated diseases like Alzheimer’s disease.