Pavitra R Y
JJM Medical college, India
Title: Evaluation of antidepressant activity of aqueous extract of the Prosopis cineraria in albino mice
Biography
Biography: Pavitra R Y
Abstract
Depression is the most prevalent mental disorder. Basic neuroscience offers the promise of improving our understanding of disease pathophysiology, identifying novel mechanisms that can be targeted by more effective pharmacotherapies and screening of herbal sources of drugs. The leaves of Prosopis cineraria are selected for evaluating its antidepressant due to its traditional use in the management of various CNS disorder. Aim of the study: To evaluate the antidepressant activity of aqueous extract of the Prosopis cineraria in albino mice. Materials and methods: Albino mice -24, Plastic cylinder, Drugs-Imipramine 15mg/kg, Aqueous extract of Prosopis Cineraria [AEPC] 100mg/kg and 200mg/kg. A total of 24 Albino mice will be divided into four groups of 6 animals each using forced swimming method. Group I served as control which received distilled water. Animals of group II received standard drug Imipramine at a dose of 15mg/kg. Group III received the AEPC orally at a dose of 100 mg/ kg. Group IV received the AEPC orally at a dose of 200 mg/ kg. Drugs were dissolved in distilled water and given orally one hour before the experiment. Results: Analysis is done using ANOVA and Post hoc analysis. Immobility time decreased with increase in the dose of aqueous extract of Prosopis cineraria [AEPC] 200mg/kg > 100mg/kg with significant p value and is comparable with standard drug imipramine 15mg/kg.
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