Pallavi M Kamath
JJM Medical college, India
Title: Evaluation of anti-convulsant activity of ethanolic extract of Murraya koenigii leaves in Wistar rats
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Biography: Pallavi M Kamath
Abstract
Murraya koenigii, commonly known as curry leaf, is a tropical-subtropical tree of family Rutacea which is native to India. The leaves of Murrya koenigii is commonly used as seasoning for curries. It is also used traditionally for the treatment of epilepsy. The aim of the present study is to evaluate the anticonvulsant activity of ethanolic extract of Murraya koenigii in wistar rats using pentylenetetrazole (PTZ) induced seizure model and maximal electroshock seizure (MES) model. Thirty adult rats of both sexes weighing 150-200g were equally distributed into five groups of six each and subjected to seizures induced by PTZ and MES. The ethanolic extract of Murraya koenigii 500mg/kg, 250mg/kg, 125mg/kg were studied for its anticonvulsant activity. The standard being Sodium Valproate 200mg/kg and Control being suspending agent- 1% tween 80 . All drugs were given orally one hour before the artificial induction of seizure. The test drug showed statistically significant result compared to control in both PTZ and MES models.
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