Pharmacognosy, Phytochemistry & Natural Products

Biography

Biography: Damayanthi Dalu

Abstract

The present investigation was aimed to evaluate the traditional claim of Ventilago maderaspatana (V.maderaspatana) in diabetes. Furthermore antihyperlipidemic and antioxidant properties were evaluated since hyperlipidemia and free radical damage leads to diabetes. Hence the present study was aimed to evaluate antidiabetic, antihyperlipidemic and antioxidant activity. Antidiabetic activity was evaluated by oral glucose tolerance test and streptozotocin-induced model. Antihyperlipidemic activity was evaluated by estimating lipid levels. In addition Ventilago maderaspatana was also evaluated for antioxidant activity employing catalase, lipid peroxidase and glutathione reductase methods. By soxhlet extraction process alcoholic, hydroalcoholic, chloroform and petroleum ether extracts were obtained. All these extracts except petroleum ether were evaluated for toxicity unto 3000 mg kg-1. In oral glucose tolerance test chloroform extract did not produce significant glucose lowering effect. Alcoholic and hydroalcoholic extracts of Ventilago maderaspatana elicited significant glucose tolerance effect. Hence VMAE and VMHAE were screened further by streptozocin induced diabetic model. VMAE and VMHAE significantly lowered blood glucose, triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, creatinine, urea and increased HDL cholesterol, serum insulin and liver glycogen levels when compared to standard drug glibenclamide (10 mg kg-1). V.maderaspatana also increased catalase levels and decreased lipid peroxidase and glutathione reductase. VMAE and VMHAE elicited significant dose-dependent antidiabetic, antihyperlipidemic and antioxidant activity. VMHAE at 500 mg kg-1 induced more significant antidiabetic activity than VMAE (500 mg kg-1). VMAE at 500 mg kg-1 elicited more antihyperlipidemic and antioxidant activity compared to VMHAE (500 mg kg-1).