Day 3 :
- B2B Meetings & Networking
Location: Hotel Grand Mercure Sao Paulo Ibirapuera
Session Introduction
Sana Kanwal
Hamdard Institute of Pharmaceutical Sciences, Islamabad
Title: A Descriptive cross sectional study assessing perceptions and knowledge of pharmacists regarding use of complementary and alternative medicines (CAM) in twin cities
Biography:
Sana Kanwal completed her Pharm D from Riphah international university, Islamabad and MS in Pharmacy practice from Hamdard institute of pharmaceutical sciences. I have 5 publications in the area of clinical pharmacy and pharmacy practice. Now a day I am serving as a lecturer of clinical pharmacy, in the pharmacy department of The University of Lahore, Islamabad campus.
Abstract:
The study purports to assess perceptions and knowledge of pharmacists (hospital and community) regarding use of complementary and alternative medicines (CAM). Methodology Data was collected through self administered questionnaires. Hospital and community pharmacists from twin cities (Islamabad and Rawalpindi) were included in this study. Simple random sampling technique was employed to select community pharmacies (Rawalpindi and Islamabad) from the sampling frame. However all tertiary care/ specialized care hospitals (public/private) were visited. Convenient sampling technique was employed to collect data from both hospital and pharmacists. Data collected from practicing pharmacists via questionnaires, was coded and analyzed by using SPSS (version 16.0). Results Total 244 practicing pharmacists (community and hospital pharmacists) participated in this study, 52.9% were male while 47.1% were female. The results of the study revealed that most of the respondents (74.2%) were of the opinion that pharmacists should be provided with proper training regarding CAM use. Majority of the respondents (54.9%) were of the view that herbal products available in market don’t meet quality standard (safety and efficacy). The results indicated that knowledge of pharmacists regarding herbal remedies was inadequate. However knowledge regarding indications of herbal drug use was better than that of adverse effects and drug-herb interactions. Conclusion This study highlighted gaps in knowledge of pharmacists regarding rational use of herbal remedies. It suggested that practicing pharmacists (community/hospital) should be provided with training regarding safety and efficacy of CAM so that they become capable enough to provide adequate information to patients regarding rational use of CAM.
Sujan Banik
Noakhali Science and Technology University, Bangladesh
Title: In vivo antinociceptive, antihyperglycemic and in vitro membrane stabilization activity with phytochemical screening of methanolic extract of Garcinia lancifolia Roxb
Biography:
Will be updated soon.
Abstract:
Garcinia lancifolia Roxb. is an important unexplored medicinal plant belonging to the family Cluseaceae, which has been used traditionally to treat many diseases. No scientific validation has been made up to now on its pharmacological activity for which the present study was to investigate the antinociceptive, antihyperglycemic activity and in-vitro membrane stabilizing activity with phytochemical screening of methanolic extract of G. lancifolia whole plant. The phytochemical screening confirmed the presence of flavonoids, saponins, alkaloid, cardiac glycoside, terpenoids extensively. In peripheral antinociceptive activity assessment by acetic acid writhing inhibition method, the extract of G. lancifolia (400 and 200 mg/kg) showed significant inhibition of writhing (P<0.001) with 59.15% and 49.30% respectively compared to standard Diclofenac (54.92% inhibition). The central antinociceptive activity by the tail-immersion method, the methanolic extract at dose of 400 and 200 mg/kg showed significant analgesic activity having 78.31% (P<.0.05) and 89.95% (P<.0.01) elongation of reaction time respectively in 90 min after administration of sample compared to the standard Morphine (708.99% elongation). In the hot plate tail-flick method, the extract (300 mg/kg) showed significant (P<.0.05) analgesic activity compared to the standard Aceclofenac. In hypoglycemic activity evaluate by the most acceptable method of glucose tolerance test, the methanolic extract exhibit statistically significant (P<0.001) antihyperglycemic activity at doses of 200 and 400 mg/kg of body weight compared to standard drug Glibenclamide (10 mg/kg) at different time interval. In membrane stabilizing activity assay, clearly evident that the methanolic extracts of G. lancifolia were highly effective to prevent the lyses of erythrocytes induced by heat. During heat induced condition this extract demonstrated 71.35% inhibition of haemolysis of RBC respectively by isotonic solution. The experimental outcomes of the present study revealed that this plant possess noteworthy pharmacological activities that may be basis for further research to find possible mode of action of the plant part.
Victor Sotero
Foundation for the Sustainable in Lowland Amazonian, Peru
Title: Allelochemicals of three amazon plants identified by Gc-Ms
Biography:
V.Sotero, Doctorated at Bichemistry Pharmaceutical at FCF- USP,Director of the Circle of Medicnal Plants from Amaznian of of Foundation for the Sustainable in Lowland Amazonian (FUNDESAB-Peru). He has pulished abotu 30 papers in several scientific journals
Abstract:
The aim of this study was to realize the evaluation of the allelopathic activity of 83 vegetable species from Allpahuayo – Mishana Reserve in Peruvian Amazon, and to determine the main polar components of three species of that showed high activity. Leaves samples were collected, which were subjected to elution for two weeks to get the methanol extracts e to test the inhibition of the roots of pre-germinated seeds of Lactuca sativa. These extracts were dried in a rotary evaporator and the product subjected to column fractionation opened using silica gel No. 100, using as mobile phase methanol and obtaining the fractions according to the appropriate retention time, and meet the fractions containing similar molecules through analysis of thin layer chromatography; which were tested to evaluate their allelopathic activity against pre-germinated seeds of Lactuca sativa. In this way it was found that three species showed activity in extracts, these were the Iryanthera ulei, Duroia hirsuta and Theobroma obovatum. When performing the analysis on GC-MS. was found compounds as terpenes, phenolics and organic acids, as the following: isoeugenol, catechol, humulene in I. ulei; limonene, geranic acid, neric acid, homovanillil alcohol in D. hirsute; phenol. 2,4-bis (1.1-dimethylethyl), α ionone in T. obovatum and phytol in each.
Akkal Salah
University of Constantine, Algeria
Title: Phytochemical constituents of aerial parts of an endemic species of region arid from the apiaceae of algeria
Biography:
Will be updated soon.
Abstract:
The Apiaceae family is represented in Algeria by 28 genus and 146 species. Among this family, many plants of the genus are widely used in local herbal medicine, as they show a wide range of pharmacological activities. Many species of Apiaceae were used in folk medicine, as spices in cookery, but also as official medicinal drugs [1, 2].Thus, they account as a well-known source of essential oils and important herbal products. They are included in various pharmacopoeias as antiseptic, expectorant, diuretic, carminative, vasodilator, or spasmolytic agents [3]. The purpose of this research concerns the phytochemical and the biological study of of some genus of the Algerian flora’s medicinal plants known as Return, Formula, Bupleurum, Daucus. The diverse methods of separation and purification of the methanolic extract of these plants to obtain many constituents. Many compounds belonging to different classes of secondary metabolites were isolated for the first time from the aerial parts of some species. These include flavonoids, coumarines, terpenoides an epoxide and a sugar which contributed to the diversity of natural products in the species. The structure elucidation of the isolated compounds was based on analyses of their spectroscopic data (1D and 2D NMR, UV, MS). Structure elucidations of the phytoconstituents were achieved using various spectroscopic methods such as 1D (1H, 13C) and 2D (COSY, HMQC, HMBC, NOESY) NMR, MS, IR and UV-Vis and by comparison of their data with those of published compounds. Analyses of the extracts by gas chromatography and GC-mass spectrometry (GC-MS) tentatively identified many compounds, the various extracts and isolated compounds of this species were studied for their antioxidant and antimicrobial activities. The isolation of these biological active compounds showed the real importance to investigate plants that can be sources of new com- pounds with clinical activities
Mansour S
University of Mostaganem, Algeria
Title: Anti-inflammatory activity of the aqueous extract of Artemisia absinthium in inflammatory paw edema model in mice
Biography:
Will be updated soon
Abstract:
Artemisia absinthium (Asteraceae) is a medicinal plant used in the treatment of many diseases including inflammatory diseases component. The purpose of this study was to evaluate the anti-inflammatory activity oral administration of aqueous extract of Artemisia absinthium leaves at doses of 150 and 300 mg / kg PC, by carrageenan induced paw edema in mouse model. At the end of the experiments, histological study is conducted. Our results show that the injection of the carrageenan causes a significant increase in paw volume of the mice. Oral administration of diclofinac (50 mg / Kg bw) causes a reduction in paw volume of the mice over the six hours of experimentation. Moreover, after one hour, the percentage inhibition of the aqueous extract of Artemisia absinthium at a dose of 150 mg / kg bw was 43%, the activity increases up to the sixth hour (90%). Similarly, at a dose of 300 mg / Kg bw the inhibitory effect of the extract of Artemisia absinthium starts and gradually increases during the experimentation (77% to 96% by H1 and H6). Histological examination of paw mice treated by diclofinac and by the aqueous extract of Artemisia absinthium (150 and 300 mg / kg bw) confirm that these treatments have anti-inflammatory activity. Furthermore, at a dose 300 mg / kg bw, the inflammatory infiltrate disappears almost completely. The results of this study showed that the aqueous extract of Artemesia absinthium has an efficacy in acute paw edema in mice induced by carrageenan, with greater efficiency at a dose of 300 mg/kg bw as compared to that of 150 mg/kg bw and that of the non-steroidal anti-inflammatory.