Chanchal Garg
Maharshi Dayanand University, India
Title: Role of Natural Antioxidants in the Oxidative Stress induced Skin Photoaging
Biography
Biography: Chanchal Garg
Abstract
Photoaging is a process which depends especially on the extent of sun exposure and the quantity of melanin in the skin. The basic mechanism involved in skin aging is the oxidative stress and the formation of free radicals known as reactive oxygen species (ROS). Skin, being rich in lipids, proteins, carbohydrates, DNA etc is highly prone to the adverse effects of ROS caused by oxidative stress. It is an established fact that the epidermis of the skin possess an extremely efficient natural antioxidant defence mechanisms supported by various types of antioxidant enzymes such as peroxidases, catalases and glutathione. But the protective impact exerted by them is limited due to excessive production of reactive oxygen species, leading to skin aging. Antioxidant potential of large number of phytoconstituents obtained from plant extracts reduces the harmful effects of oxidative stress and helps in the prevention of the clinical signs of skin aging. Topical application of antioxidant substances, such as tocopherol, ascorbic acid, coenzyme Q10, plant extracts with phenolics as well as different combinations of these compounds, helps in maintaining the skin antioxidant reservoir, thus increasing the antioxidant skin defence thereby reducing the harmful effects of free radicals and oxidative stress. For example, tetrahydro curcuminoids derived from curcuminoids present in roots of Curcuma longa is capable of preventing free radical formation and also neutralising the existing free radicals, anthocyanins present in Acai palm significantly decreases the UVB induced DNA damage and free radical species in human keratinocytes. Similarly, polyphenols derived from green tea effectively destroy the free radical and reverses the aging process. Thus, antioxidants with free radical scavenging activities possess great significance in the protection and therapeutics of age-related disease involving free radicals. Present work is based on protective role of natural compounds in the oxidative stress induced Photoaging and its future potential.